XYMOGEN 5-MTHF ES - Bioactive Folate Supplement - 17,000 mcg (as Quatrefolic) - 60 Capsules

Health Benefits of Bioactive Folate

Folate plays a key role in many body functions, including the formation of normal red blood cells, homocysteine metabolism, and psychological wellbeing. It also supports the immune system and can help reduce feelings of tiredness and fatigue. For women who are pregnant or planning a pregnancy, adequate folate intake contributes to maternal tissue growth and healthy fetal development. Because 5-MTHF ES delivers the active form of folate, it works directly to support these essential processes, particularly for those who may have trouble converting synthetic folic acid.

What Is 5-MTHF and Why It Matters

5-MTHF (5-methyltetrahydrofolate) is the biologically active form of folate that your body can use right away, without needing to be converted by the MTHFR enzyme. Unlike synthetic folic acid, which must be processed in the liver, 5-MTHF is already in its usable state. This makes it an excellent choice for individuals with MTHFR gene variants, who may not efficiently convert folic acid. XYMOGEN 5-MTHF ES supplies 17,000 mcg of Quatrefolic®, a patented, water-soluble form of 5-MTHF known for its enhanced stability and absorption.

Who Can Benefit Most

This supplement is especially valuable for those who need a highly absorbable folate source. Pregnant women or those planning pregnancy have increased folate requirements, making this high-potency formula a practical option. People with MTHFR gene variations may also find 5-MTHF ES advantageous, as it bypasses the conversion step. Other candidates include older adults, individuals with digestive issues that affect nutrient absorption, and anyone looking to support methylation for overall wellness. As always, consult a healthcare professional before starting any supplement.

Recommended Dosage and Use

Each container holds 60 capsules, with a typical serving of one capsule per day. This provides 17,000 mcg of bioactive folate—far more than the recommended dietary allowance of 400 mcg for most adults and 600 mcg during pregnancy. Because 5-MTHF is so well absorbed, even lower doses can be effective, but this high-potency format is designed for those with increased needs or absorption challenges. Do not exceed the recommended dose unless directed by a healthcare provider.

Choosing a Quality Folate Supplement

When selecting a folate supplement, consider the form: bioactive 5-MTHF versus synthetic folic acid. Look for third-party testing to ensure purity and potency. XYMOGEN 5-MTHF ES is vegan, gluten-free, non-GMO, and free from common allergens such as dairy, soy, corn, peanuts, egg, and shellfish. The brand is known for evidence-based formulations and is trusted by healthcare professionals globally. Always check labels for certifications and discuss with your healthcare provider if you have specific health concerns.

Potential Side Effects and Cautions

Folate supplements are generally well-tolerated. However, very high doses of folic acid can mask a vitamin B12 deficiency, potentially leading to neurological damage. Since 5-MTHF is the active form, this risk is lower, but it is still important to ensure adequate B12 levels. The tolerable upper intake level for folic acid from supplements is 1,000 mcg per day; the safety of high-dose 5-MTHF may differ. Consult a doctor before taking high-dose folate, especially if you are on medication or have a medical condition.

Frequently Asked Questions

Can I take 5-MTHF ES if I have the MTHFR gene mutation?

Absolutely. 5-MTHF ES contains the active form of folate, which bypasses the MTHFR enzyme. This makes it ideal for individuals with MTHFR variants who may not convert folic acid efficiently.

Is this supplement safe during pregnancy?

Folate is essential during pregnancy, and 5-MTHF ES provides a high dose of bioactive folate. However, pregnant women should consult their healthcare provider before taking any supplement to ensure it meets their specific needs.

What makes Quatrefolic different from other 5-MTHF forms?

Quatrefolic is a glucosamine salt of 5-MTHF that is water-soluble and highly stable. It offers improved bioavailability compared to other forms of 5-MTHF, ensuring efficient absorption and utilization by the body.

These statements have not been evaluated by Health Canada. This product is not intended to diagnose, treat, , or prevent any disease.