THORNE Methyl-Guard - Supports Healthy Methylation* - 180 Capsules

Who Can Benefit from Methylation Support?

Are you one of the many Canadians with an MTHFR gene variation? If so, your body may struggle to convert synthetic folic acid into its active form. THORNE Methyl-Guard provides a solution by supplying pre-methylated folate (5-MTHF) and methylcobalamin, bypassing this genetic bottleneck. Vegans and vegetarians, who often have lower B12 intake, can also benefit. Older adults, athletes, and those under physical stress may require additional methylation support. Trusted by over 100 professional sports teams, Thorne is the #1 most recommended clinical brand by consumers and healthcare practitioners (based on a 2026 independent survey), making Methyl-Guard a popular choice for high-quality methylation support.*

Key Benefits for Heart, Brain, and Bone Health

Proper methylation supports cardiovascular health by facilitating homocysteine metabolism, which helps maintain arterial flexibility and heart function.* For the brain, active B vitamins contribute to nerve cell communication and cognitive function. Methylation also influences bone metabolism, supporting bone density and strength.* Each serving delivers 2 mg of 5-MTHF (as calcium folinate), 1 mg of methylcobalamin, 20 mg of vitamin B6 (as pyridoxal 5'-phosphate), and 500 mg of betaine anhydrous — a comprehensive dose to support these vital processes.*

What Makes THORNE Methyl-Guard Special?

Not all B vitamin supplements are created equal. Many contain synthetic folic acid and cyanocobalamin, which require enzymatic conversion and may not be effective for everyone. THORNE Methyl-Guard uses only the active, methylated forms: 5-MTHF (calcium folinate) — the same form found in nature, and methylcobalamin — the coenzyme form of B12. Betaine acts as a direct methyl donor, and vitamin B6 as P-5-P is the active coenzyme form. The formula is free from gluten, dairy, and soy, and is manufactured in a cGMP-compliant facility. Third-party testing ensures purity and potency.

What Is Methyl-Guard and Why Does Methylation Matter?

Methylation is a fundamental biochemical process that occurs in every cell of your body. It plays a critical role in DNA synthesis, gene expression, neurotransmitter production, detoxification, and homocysteine regulation. When methylation pathways are compromised, it can affect cardiovascular, neurological, and skeletal health. THORNE Methyl-Guard is a targeted supplement designed to support optimal methylation by providing the most bioavailable forms of key nutrients: active folate (5-MTHF), active vitamin B12 (methylcobalamin), vitamin B6 (as pyridoxal 5'-phosphate), and betaine (trimethylglycine). These ingredients work synergistically to promote healthy methylation and help maintain homocysteine levels already within a normal range.*

How to Choose a Methylation Support Supplement

When selecting a methylation supplement, consider the following: Ensure folate and B12 are in their active forms (5-MTHF and methylcobalamin). Look for additional methyl donors like betaine or SAMe. Check for vitamin B6 in its active form (P-5-P). Choose a product free from unnecessary additives and allergens. Opt for a reputable brand with transparent quality practises. THORNE meets all these criteria, offering a potent, well-absorbed formula in easy-to-swallow capsules.

Frequently Asked Questions About Methyl-Guard

How should I take Methyl-Guard?

The recommended dose is 2 capsules daily with food. One bottle of 180 capsules provides a 90-day supply. For best absorption, take with a meal containing some fat.

Can Methyl-Guard be taken with other supplements?

Yes, it pairs well with other Thorne products. However, if you are taking medications (especially blood thinners) or have a medical condition, consult your healthcare practitioner before use.

Is Methyl-Guard suitable for vegans?

Yes. The capsules are made from hypromellose (vegetable cellulose) and the formula contains No animal-derived ingredients.

Does Methyl-Guard contain folic acid?

No. It contains calcium folinate (5-MTHF), the active form of folate, making it ideal for those with MTHFR gene variations.

*This product is a natural health product and is not intended to diagnose, treat, , or prevent any disease. Always read the label and follow directions for use.