Swanson Folate 5-Methyltetrahydrofolic Acid – High Potency, Bioactive Form 800 mcg DFE, 30 Veg Caps (2-Pack)

What Is 5-Methyltetrahydrofolate (5-MTHF)?

Folate (vitamin B9) is an essential nutrient that supports numerous processes in the body, from red blood cell production to tissue growth. The form of folate used in this supplement, 5-MTHF, is the same active compound that your cells can utilize without any further conversion. Unlike folic acid — the synthetic form found in many supplements and fortified foods — 5-MTHF is ready to work for you, making it a smart choice for individuals with genetic variations in the MTHFR enzyme.

Folic Acid vs. 5-MTHF: What's the Difference?

Synthetic folic acid needs to be converted by the liver into active 5-MTHF via the MTHFR enzyme. However, up to 60% of the population carries genetic variants that reduce the efficiency of this conversion. By choosing 5-MTHF directly, you bypass this step — ensuring your body gets the active folate it needs, regardless of your genetics. This is especially relevant for those with MTHFR mutations, as well as for others who may benefit from a more direct source of folate.

Key Benefits of Bioactive Folate

• Supports red blood cell formation: Folate contributes to normal red blood cell production, which is essential for oxygen transport throughout the body.
• Promotes cardiovascular health: Adequate folate intake helps maintain normal homocysteine metabolism, supporting heart and blood vessel health.
• Important for prenatal health: Adequate folate before and during early pregnancy may reduce the risk of neural tube defects. Health Canada recommends that women who could become pregnant take a daily supplement of 400 mcg folic acid (or equivalent). This product provides 800 mcg DFE per capsule.
• Supports tissue formation and cell division: Folate is involved in DNA synthesis and cell division, making it vital during periods of rapid growth, such as pregnancy and infancy.

These statements have been evaluated by Health Canada and are compliant with the Natural Health Products Regulations. This product is not intended to diagnose, treat, , or prevent any disease.

Who Might Benefit from This Supplement?

• Women of childbearing age and pregnant women: Folate is critical before and during early pregnancy to support foetal development and reduce the risk of neural tube defects.
• Individuals with MTHFR gene variants: Those with common MTHFR mutations may benefit from 5-MTHF as it bypasses the conversion step that can be impaired.
• Older adults: Aging can reduce the body's ability to convert folic acid, making active folate a smart choice for maintaining healthy levels.
• Anyone with a diet low in folate-rich foods: Such as leafy greens, legumes, and fortified grains.

How Much Folate Should You Take?

The Recommended Dietary Allowance (RDA) for folate is 400 mcg DFE for most adults, 600 mcg DFE during pregnancy, and 500 mcg DFE while breastfeeding. This product provides 800 mcg DFE per serving (one capsule), which is a high-potency dose. The tolerable upper intake level from supplements is 1,000 mcg DFE per day. Always consult your health care provider to determine the appropriate dose for your individual needs.

How to Choose a Quality Folate Supplement

• Form: 5-MTHF (as calcium salt) is more bio-available than folic acid for most people.
• Dosage: Choose a dose that aligns with your specific needs — this product supplies 800 mcg DFE per serving.
• Quality assurance: Swanson follows Good Manufacturing Practises (GMP) and their products undergo testing for purity and potency.
• Dietary preferences: These capsules are vegetarian-friendly.

Potential Side Effects and Precautions

Folate is generally well tolerated when taken as recommended. However, high doses (above 1,000 mcg) may mask a vitamin B12 deficiency, particularly in older adults. If you have pernicious anaemia or a known B12 deficiency, consult your health care provider before using this supplement. Do not exceed the recommended dose. Keep out of reach of children. Store in a cool, dry place.

Frequently Asked Questions

Can I take this if I have an MTHFR mutation?

Yes. 5-MTHF is the preferred form for individuals with MTHFR gene variants because it bypasses the conversion step that may be impaired.

Is this product suitable for vegans?

Yes, the capsules are vegetarian-friendly. The product does not contain animal-derived ingredients.

How should I store this supplement?

Store in a cool, dry place away from direct sunlight. Keep the bottle tightly closed when not in use.

Can I take this with other medications?

Folate may interact with certain medications such as methotrexate or antiepileptics. Consult your health care provider if you are taking prescription medications.