Renue By Science TMG | High Strength TMG Supplements | 120 Trimethylglycine Capsules - 900 mg TMG per Serving with Vitamin B12, Vitamin B6, Folate, and Zinc | Made in the USA & Third-party tested

Key Benefits of This TMG Formula

Renue By Science combines 900 mg of pure TMG per serving with synergistic nutrients: vitamin B12 (30 mcg), vitamin B6 (5.1 mg), folate (1000 mcg), and zinc (12 mg). These nutrients work together within the methylation cycle. B12 and folate are required for the remethylation of homocysteine, while B6 supports transsulfuration. Zinc acts as a cofactor for numerous enzymes involved in DNA synthesis and antioxidant defence.

• Supports methylation pathways – Provides methyl donors and cofactors for optimal cellular function.
• Helps maintain healthy homocysteine levels – Promotes cardiovascular health by supporting homocysteine metabolism.
• Supports energy production – Contributes to normal energy yielding metabolism through B vitamins.
• Promotes cognitive function – Adequate methylation is essential for neurotransmitter balance and mental clarity.
• Supports DNA integrity – Methylation plays a key role in DNA repair and gene regulation.
• May support liver function – TMG helps in the metabolism of fats and supports liver health.

What Makes Renue By Science TMG Special?

This formula uses acid-resistant enteric capsules, a key differentiator. Standard capsules dissolve in the stomach, where stomach acid can degrade TMG and reduce absorption. Enteric capsules survive the acidic environment and release their contents in the small intestine, the primary site for nutrient uptake. This ensures maximum bioavailability and efficacy.

Each batch is manufactured in a GMP-compliant, FDA-registered facility in the USA and undergoes third party testing for purity and potency. The product is allergen-free, making it suitable for individuals with common dietary restrictions.

Who Can Benefit from a TMG Supplement?

TMG is particularly beneficial for individuals with MTHFR gene mutations, which can hinder the body's ability to methylate effectively. Those with elevated homocysteine levels, vegans (who may lack choline, a TMG precursor), and older adults with reduced methylation capacity may also benefit. Additionally, athletes and active individuals use TMG to support energy metabolism and recovery. People experiencing fatigue, brain fog, or mood imbalances due to compromised methylation may find this formula helpful.

If you experience fatigue, brain fog, or mood imbalances, compromised methylation could be a contributing factor. This formula provides a comprehensive approach to restore and maintain methylation balance.

How to Take TMG Methylation Essentials

The recommended serving is 2 capsules daily with a meal, or as directed by your health-care professional. Taking with food may improve tolerance. Do not exceed the recommended dosage. If you are pregnant, nursing, or taking medication, consult your doctor before use. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

Frequently Asked Questions

Can I take TMG with other supplements?

Yes, TMG pairs well with other methylation support nutrients like methylated B vitamins, magnesium, and choline. However, if you are taking blood-thinning medications or have specific health conditions, consult your healthcare practitioner.

What is the difference between TMG and betaine HCl?

TMG (trimethylglycine) is a methyl donor for methylation, while betaine HCl is used as a digestive aid to increase stomach acid. They are different compounds with distinct functions.

Is this product suitable for vegans?

The capsules are made from hypromellose (vegetarian) and are free from animal-derived ingredients. However, check with the manufacturer for the most current ingredient information.

Can I take this on an empty stomach?

It is recommended to take with a meal to enhance absorption and reduce the chance of gastrointestinal discomfort. The enteric capsule design ensures that TMG is released in the small intestine regardless of food intake, but taking with food may still be beneficial.

What Is TMG and Why Is It Important for Methylation?

Discover Renue Science High — Trimethylglycine (TMG), also known as betaine, is a naturally occurring compound found in foods like beets, spinach, and whole grains. It plays a central role in the body's methylation pathways. Methylation is a biochemical process that occurs billions of times every second, influencing everything from DNA repair and gene expression to neurotransmitter production and detoxification. TMG acts as a methyl donor, donating a methyl group to homocysteine to convert it into methionine, a key amino acid. This helps maintain healthy homocysteine levels—an important marker for cardiovascular and cognitive health.

Many factors can impair methylation, including genetic variations like MTHFR, poor diet, stress, and aging. Supplementing with TMG provides the methyl groups needed to support optimal methylation, promoting cellular function, DNA integrity, and healthy aging.

Health Canada Disclaimer: This product is a natural health product. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking any medications. Keep out of reach of children. Always read the label and follow directions for use.