Why Choose Klaire Labs P-5-P?

For over 50 years, Klaire Labs has earned the confidence of healthcare practitioners across North America by delivering pure, potent supplements. Their P-5-P provides the bioactive coenzyme form of vitamin B6, ensuring your body gets the most effective support possible. Made in a facility with rigorous quality controls, each hypoallergenic capsule is free from common allergens like dairy, gluten, soy, and corn, and contains No artificial colours, flavors, or preservatives. This makes it an excellent choice for individuals with sensitivities or those following a clean supplement regimen.

What Is Pyridoxal-5-Phosphate (P-5-P)?

Vitamin B6 appears in several chemical forms, but pyridoxal-5-phosphate (P-5-P) is the active coenzyme that your body can utilize immediately. Unlike pyridoxine hydrochloride (HCl), which must be converted in the liver, P-5-P is ready to work without delay. This is particularly advantageous for people with reduced liver function or genetic variations (such as MTHFR polymorphisms) that impair conversion. P-5-P serves as a cofactor for more than 50 enzymatic reactions, including those involved in amino acid metabolism, neurotransmitter production (serotonin, dopamine), red blood cell formation, and fatty acid metabolism.

Health Benefits of Vitamin B6 (P-5-P)

Vitamin B6 in its P-5-P form contributes to many vital bodily functions. It helps the body metabolise carbohydrates, fats, and proteins to release energy, supporting normal energy-yielding metabolism. It also promotes normal homocysteine metabolism, which is important for cardiovascular health. Additionally, vitamin B6 contributes to the formation of red blood cells and supports the normal function of the immune system. Many users appreciate its role in regulating hormonal activity, which may help maintain a balanced mood, particularly during PMS or menopause, leading to more consistent energy and mental clarity.

How to Choose a Vitamin B6 Supplement

When selecting a vitamin B6 supplement, the form matters: P-5-P is more bioavailable than pyridoxine HCl, especially for those with liver concerns or MTHFR variants. Dosage is also key—choose an amount that aligns with your health goals without exceeding safe limits. Quality is paramount; look for products that are hypoallergenic and free from unnecessary additives. Klaire Labs P-5-P meets these criteria, having been developed in collaboration with clinicians to ensure purity and potency.

Recommended Dosage and Usage

Each vegetarian capsule of Klaire Labs P-5-P supplies 30 mg of pyridoxal-5-phosphate. This dose is within the tolerable upper intake level of 100 mg per day for adults. While the Recommended Dietary Allowance (RDA) for vitamin B6 ranges from 1.3 to 2.0 mg, higher amounts are often used therapeutically under professional supervision. For best results, take one capsule daily with food or as directed by your healthcare practitioner. Do not exceed the recommended dose unless advised by a qualified health professional.

Potential Side Effects and Safety

Vitamin B6 is generally safe at appropriate doses. However, prolonged intake of very high doses (over 200 mg daily) may lead to peripheral neuropathy—numbness and tingling in the hands and feet. The safe upper limit is 100 mg per day for adults. If you are pregnant, nursing, or taking medications such as levodopa or certain antibiotics, consult your healthcare practitioner before use. Keep out of reach of children. As with any supplement, discontinue use if adverse reactions occur and seek medical advice.

This product has not been evaluated by Health Canada. It is not intended to diagnose, treat, , or prevent any disease.