DAVINCI Labs - 5-MTHF/B12 MC 2000, 60 Capsules

Who Should Consider This Supplement?

If you need an extra boost of B12 and folate in a form your body can use right away, this supplement is for you. Pregnant women will appreciate the support for fetal development, while older adults often require supplementary B12 due to reduced absorption. Those with elevated homocysteine levels may also benefit for cardiovascular health, and vegetarians or vegans can rely on this formula to fill dietary gaps. The bioactive forms make it particularly useful for individuals with MTHFR gene variants that impair folate metabolism.

What Is 5-MTHF/B12 MC 2000?

This targeted formula from DAVINCI Labs delivers two essential nutrients—vitamin B12 as methylcobalamin and folate as 5-methyltetrahydrofolate (5-MTHF)—in a convenient capsule. Each serving provides 2,000 mcg of methylcobalamin and 1,000 mcg DFE of folate. Because these are the active coenzyme forms, your body can use them immediately, bypassing the conversion steps often needed with synthetic alternatives like cyanocobalamin and folic acid. This is especially beneficial for individuals with common MTHFR polymorphisms that hinder conversion.

Key Benefits of 5-MTHF and Methylcobalamin

Heart and Cardiovascular Health: Both B12 and folate help maintain healthy homocysteine levels, an amino acid linked to cardiovascular risk when elevated. By supporting homocysteine metabolism, this supplement contributes to overall heart health.

Brain Function and Nervous System: Methylcobalamin supports myelin sheath formation and neurotransmitter synthesis, which are critical for cognitive function and nerve signaling. The combination with folate further supports brain health in adults and proper neural tube closure in developing fetuses.

Healthy Pregnancy: Folate is widely recognized for its role in preventing neural tube defects during the first trimester. The 5-MTHF form is directly usable, making it ideal for women with MTHFR variants.

Energy Production: Vitamin B12 plays a key role in converting food into cellular energy. While not a stimulant, adequate B12 helps reduce fatigue and supports metabolic efficiency.

What Makes This Formula Different?

Many supplements contain cyanocobalamin and folic acid, which require liver conversion to become active. DAVINCI Labs uses methylcobalamin and 5-MTHF—the naturally occurring bioactive forms—so your body can use them immediately. This is particularly advantageous for neurological health because methylcobalamin participates in methylation reactions, including SAMe production, which supports mood and detoxification. The 5-MTHF form bypasses the MTHFR enzyme step, making it a smart choice for those with common genetic variations.

How to Use and Suggested Dosage

Take one capsule daily with food and a glass of water, or as directed by your healthcare practitioner. Each bottle contains 60 capsules—a two-month supply at the recommended dose. Do not exceed the suggested use unless advised by a physician. Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Product Features at a Glance

• Bioactive Forms: Methylcobalamin (B12) and 5-MTHF (folate) for superior absorption and utilization
• High Potency: 2,000 mcg B12 and 1,000 mcg DFE folate per capsule
• Targeted Support: Formulated for pregnancy, heart health, and brain function
• Quality-Focused: Manufactured by DAVINCI Labs, a leader in nutritional research
• Convenient: Once-daily capsule, easy to incorporate into your routine

Frequently Asked Questions

Can I take this supplement if I'm not pregnant?
Absolutely. While it is beneficial during pregnancy, anyone needing additional B12 and folate support—including older adults, vegetarians, and those with methylation issues—can use it.

Is it safe to take with other medications?
Generally, B12 and folate are safe, but always consult your doctor before starting any new supplement, especially if you take anticonvulsants or methotrexate.

How does this compare to B12 shots?
Oral methylcobalamin in high doses is well-absorbed and can be as effective as injections for many people. However, individuals with severe deficiency or absorption issues may require injections. Discuss with your healthcare provider.

Are there any side effects?
B12 and folate are water-soluble and generally well-tolerated. Some people may experience mild digestive upset. If you experience any adverse reactions, discontinue use and consult a healthcare practitioner.

These statements have not been evaluated by Health Canada. This product is not intended to diagnose, treat, , or prevent any disease. Always consult your health-care practitioner before taking this supplement. If you are pregnant or breastfeeding, consult a health-care practitioner prior to use.