Skip to product information
1 of 10

Clear Formulae Bioactive SAM-e 500mg - High Strength SAM-e Supplement with Biologically Active S,S Form for Liver and Mood Support - Vegan, Non-GMO, Preservative (same)-Free - Made in the USA (120 Servings)

Clear Formulae Bioactive SAM-e 500mg - High Strength SAM-e Supplement with Biologically Active S,S Form for Liver and Mood Support - Vegan, Non-GMO, Preservative (same)-Free - Made in the USA (120 Servings)

Regular price $76.87 CAD
Sale price $76.87 CAD Regular price
Save % Sold out

Buy more, save more

Clear Formulae Bioactive SAM-e 500mg - High Strength SAM-e Supplement with Biologically Active S,S Form for Liver and Mood Support - Vegan, Non-GMO, Preservative (same)-Free - Made in the USA (120 Servings)

Regular price $76.87
Sale price $76.87 Regular price
Save % Sold out
  • Ach Direct Debit
  • Amazon
  • American Express
  • Apple Pay
  • Bancontact
  • Diners Club
  • Discover
  • Google Pay
  • Mastercard
  • PayPal
  • Shop Pay
  • Visa

Who Should Consider SAM-e?

If you're an adult looking to support your emotional well-being, maintain joint flexibility, or promote healthy liver function, SAM-e may be the natural option you need. This supplement is particularly beneficial for those experiencing occasional low mood, active individuals wanting to protect joint health, or anyone seeking to enhance their body's detoxification pathways. As always, consult a health-care professional before starting any new supplement, especially if you are pregnant, nursing, or have a medical condition.

What Is Bioactive SAM-e?

S-adenosyl methionine (SAM-e) is a molecule your body produces naturally that plays a key role in methylation, a process essential to neurotransmitter production, cartilage maintenance, and liver detoxification. Clear Formulae Bioactive SAM-e 500 mg provides this compound in its biologically active S,S isomer form, ensuring optimal absorption. Each capsule delivers 500 mg, making it convenient for daily use.

Key Benefits of SAM-e Supplementation

SAM-e has been studied for its role in supporting a healthy mood, joint comfort, and liver function. Here's how it may help:

  • Mood Support: Involved in the synthesis of serotonin and dopamine, SAM-e may help maintain a positive outlook and emotional balance.
  • Joint Health: As a building block for cartilage, SAM-e supports joint flexibility and comfort, making it a valuable addition to a joint health regimen.
  • Liver Function: Essential for detoxification pathways, SAM-e helps maintain healthy liver enzyme levels.

These claims are based on the recognized roles of SAM-e. Individual results may vary.

Top Features of Clear Formulae Bioactive SAM-e

  • Biologically Active S,S Form: Enhanced stability and absorption for maximum effectiveness.
  • High Strength 500 mg: Potent dose in a single daily capsule.
  • Vegan & Non-GMO: Suitable for plant-based lifestyles and free from genetically modified ingredients.
  • Preservative (same)-Free: No artificial preservatives, ensuring a clean supplement.
  • Made in the USA: Manufactured in a cGMP compliant facility following strict quality guidelines.
  • Allergen-Free: Free from dairy, gluten, soy, and wheat.

Customers appreciate the quality and potency, noting its effectiveness for mood and joint support. The strong odour is a natural characteristic of SAM-e and indicates freshness — refrigeration can help minimise it.

How to Choose the Best SAM-e Supplement

Not all SAM-e supplements are created equal. When selecting, consider the form of SAM-e, dosage, and purity. Clear Formulae uses the biologically active S,S form (as S-adenosyl-L-methionine disulfate tosylate) for enhanced stability and bioavailability. A 500 mg dosage is standard for therapeutic benefit. Look for supplements free from unnecessary additives and made in a GMP-certified facility. This product is vegan, non-GMO, and preservative (same)-free, meeting high quality standards.

FAQs About SAM-e

How should I take SAM-e?

Take one capsule daily with water. For best absorption, take on an empty stomach or as directed by your health care provider.

Are there any side effects?

SAM-e is generally well-tolerated. Some people may experience mild gastrointestinal discomfort. If you have bipolar disorder or are taking antidepressants, consult your doctor before use.

Why does SAM-e have a strong smell?

A strong odour is normal for SAM-e supplements and indicates potency. Storing the bottle in the refrigerator can reduce the smell without affecting the product.

Can I take this with other supplements?

SAM-e can be taken alongside other supplements, but it's best to consult a health-care professional to avoid interactions.

This product is a natural health product. Always read and follow the label. Do not exceed recommended dose. If you have bipolar disorder or are taking antidepressants, consult your healthcare practitioner. Keep out of reach of children.

Delivery in Canada

Orders are prepared with clear Canada delivery expectations from the product page through dispatch. Delivery estimates are shown before checkout where available, and tracking details are sent after the order leaves fulfilment so customers can follow the parcel and plan around the expected arrival window.

Returns and support

Vitamin4CA offers straightforward post-purchase support with a clear returns process. Please check the store returns policy before sending an item back, as final eligibility may depend on product condition, packaging integrity and whether the return request is started within the stated return window.

How to choose

Use the product description, ingredient list, serving information and available variants to compare supplement options. Always check the full ingredient list, directions for use and any allergen information on the product packaging before taking any dietary supplement.

Ingredients and important information

Ingredient lists and formulations may vary by batch or supplier. Always check the product packaging for the most up-to-date information. Dietary supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. If you are pregnant, nursing, taking medication or have a medical condition, consult your healthcare professional before use.

View full details
  • Free standard deliveryUsually 2–7 business days to Canada, after 1–3 days to prepare
  • 30-day returnsOn unopened items in original packaging
  • Secure checkoutProcessed by Shopify with major cards accepted
  • Real supportEmail or phone, answered by our team

☆☆☆☆☆

Buying guide and questions

Supplement guide

Clear Formulae Bioactive SAM-e 500mg - High Strength SAM-e Supplement with Biologically Active S,S Form for Liver and Mood Support - Vegan, Non-GMO, Preservative (same)-Free - Made in the USA (120 Servings) at Vitamin4CA

Who Should Consider SAM-e?If you're an adult looking to support your emotional well-being, maintain joint flexibility, or promote healthy liver function, SAM-e may be the natural option you need. This supplement is pa...

Category Blended Vitamin & Mineral Supplements
Delivery area Canada
Checkout Secure checkout
Brand Clear Formulas
Price $76.87
Availability In stock
bioactiveClear Formulasdairy-freegluten-freehigh strengthjoint supportliver healthmade in USAmood supportnon-GMO

How to choose if this supplement fits your routine

Read the ingredient list, check the serving size and directions for use. Consider the supplement form (tablet, capsule, liquid) and whether it suits your dietary requirements. Dietary supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.

Questions about Clear Formulae Bioactive SAM-e 500mg - High Strength SAM-e Supplement with Biologically Active S,S Form for Liver and Mood Support - Vegan, Non-GMO, Preservative (same)-Free - Made in the USA (120 Servings)

Is Clear Formulae Bioactive SAM-e 500mg - High Strength SAM-e Supplement with Biologically Active S,S Form for Liver and Mood Support - Vegan, Non-GMO, Preservative (same)-Free - Made in the USA (120 Servings) available for Canada customers?

Yes. This product is currently available on Vitamin4CA with Canada-wide delivery.

How should I compare this with similar supplements?

Compare the active ingredients, serving size, number of servings per container, supplement form, brand reputation and price per serving. Check allergen information if relevant to your dietary needs.

Where can I find delivery and returns information?

Delivery information is shown near the add to cart area. Returns guidance is available on the product page and full terms are covered in the store returns policy.