Carlyle 5-MTHF L Methylfolate 1mg | 120 Capsules | Non-GMO & Gluten Free Supplement

Who Should Take 5-MTHF?

If you are planning a pregnancy, have an MTHFR gene variant, or want to support your cardiovascular health, 5-MTHF (L-methylfolate) could be a valuable addition to your routine. This active form of folate is especially beneficial for women of childbearing age — Health Canada recommends 400–800 mcg of folate daily to reduce the risk of neural tube defects. Individuals with MTHFR mutations, which affect up to 40% of the population, may struggle to convert folic acid into its usable form; methylfolate bypasses this step. Older adults, whose absorption of folate often declines with age, may also benefit. As always, consult your healthcare provider before starting any new supplement.

What Is 5-MTHF L Methylfolate?

5-MTHF (L-methylfolate) is the biologically active form of folate, also known as vitamin B9. Unlike synthetic folic acid, which requires conversion in the body, L-methylfolate is ready for immediate use. This makes it an excellent choice for individuals with genetic variations like MTHFR that impair folate metabolism. Carlyle's 5-MTHF provides 1 mg (1,000 mcg) of L-methylfolate per capsule, delivering a potent dose of this essential nutrient.

Health Benefits of 5-MTHF

Folate plays a critical role in many bodily functions. As the active form, 5-MTHF may help support:

• Normal homocysteine metabolism – Elevated homocysteine is a risk factor for cardiovascular issues, and folate helps convert it to methionine.
• Red blood cell formation – Folate contributes to normal blood cell production, which can help reduce tiredness and fatigue.
• Fetal development – Adequate folate intake during pregnancy supports neural tube development in the baby.
• DNA synthesis and cell division – Folate is essential for the creation of new cells, making it important for growth and repair.

This product is licensed by Health Canada as a natural health product. It is not intended to diagnose, treat, , or prevent any disease. Always read the label and follow directions for use.

Recommended Dosage

Each capsule of Carlyle 5-MTHF delivers 1 mg (1,000 mcg) of L-methylfolate. The recommended dietary allowance (RDA) for folate is 400 mcg DFE for most adults, but pregnancy increases the need to 600–800 mcg. Many prenatal supplements provide 400–800 mcg of folic acid; switching to an equivalent dose of methylfolate may benefit those with MTHFR mutations. The tolerable upper intake level from supplementary folate is 1,000 mcg (1 mg) per day. As always, follow the dosage on the label or your healthcare provider's advice.

Folic Acid vs. Methylfolate: Which Is Better?

Standard supplements typically contain folic acid, the synthetic form. Once ingested, folic acid must be converted by the liver into active 5-MTHF. However, this conversion is inefficient in many people due to genetic factors or health conditions. L-methylfolate is already active, meaning it can be used directly by the body. This makes it a superior choice for:

• Individuals with MTHFR polymorphisms
• Those with digestive issues that impair absorption
• People seeking a more bioavailable form of folate

The trade-off is cost: methylfolate supplements are typically more expensive than folic acid. For most healthy individuals without absorption issues, folic acid is effective, but for targeted support, methylfolate offers a distinct advantage.

How to Choose a Quality 5-MTHF Supplement

Not all supplements are created equal. When selecting a methylfolate product, consider:

• Third-party testing – Look for certifications like USP, NSF, or independent lab verification to ensure purity and potency.
• Form – Ensure the label states “L-methylfolate” or “5-MTHF” (not calcium folinate or folic acid).
• Dosage accuracy – Verify the amount per serving; 1 mg is a common therapeutic dose.
• Free from allergens – Carlyle's formula is naturally free of gluten, wheat, yeast, lactose, soy, artificial flavors, and preservatives. It is also Non-GMO.

Always store supplements in a cool, dry place and check expiration dates.

Potential Side Effects and Precautions

5-MTHF is generally safe and well-tolerated. However, some individuals may experience mild digestive upset, nausea, or sleep disturbances, especially at higher doses. High levels of folate can mask a vitamin B12 deficiency, which is common in older adults and vegetarians. If you suspect B12 deficiency, have your levels checked before supplementing with high-dose folate. Do not exceed the recommended dosage without medical supervision.

Frequently Asked Questions

Can I take 5-MTHF with other B vitamins?
Yes, methylfolate works synergistically with vitamin B12 (especially methylcobalamin) and vitamin B6. Many active B-complex formulations include all three.

Is 1 mg of L-methylfolate too much?
For most adults, 1 mg falls within the safe upper limit of supplementary folate. However, if you are not pregnant or have No special needs, 400–800 mcg may suffice. Consult your healthcare provider.

Does 5-MTHF help with depression?
Some studies suggest that L-methylfolate may enhance the effectiveness of antidepressants, but it is not approved by Health Canada for treating depression. Always discuss with a doctor.

When should I take it?
Take with or without food. Consistency is key, so pick a time that works for your daily routine.