5-MTHF Methylfolate 5mg, Quatrefolic® for MTHFR Support, 60-day Supply

Why Choose Active Folate for MTHFR Support?

If you have an MTHFR gene variant, your body may struggle to convert folic acid into its active form, 5-methyltetrahydrofolate (5-MTHF). This supplement provides 5000mcg of Quatrefolic®, a fourth-generation, glucosamine-bound 5-MTHF that bypasses the conversion step. It’s a direct source of active folate, making it a smart choice for individuals with MTHFR mutations, those planning pregnancy, or anyone seeking a reliable, bio-available form of vitamin B9.

Who Should Consider This Supplement?

• Women planning a pregnancy or during pregnancy: Adequate folate is critical for foetal neural tube development, especially in the first weeks.
• Individuals with MTHFR gene variants: The active form bypasses the MTHFR enzyme, providing direct support.
• People with elevated homocysteine levels: Active folate helps support normal homocysteine metabolism, a key factor for cardiovascular health.
• Those with low dietary folate intake: If you don’t eat enough leafy greens, beans, or citrus, supplementation can fill the gap.
• Older adults: Folate absorption naturally declines with age, making a potent, absorbable form beneficial.

Always consult your health care provider before starting a new supplement, especially if you have health conditions or take medications.

Health Benefits of Active Folate

Folate contributes to many physiological functions. Health Canada recognizes structure-function claims for active folate, including:

• Supports normal homocysteine metabolism – elevated homocysteine is a risk factor for cardiovascular health.
• Contributes to the reduction of tiredness and fatigue – folate plays a role in energy metabolism.
• Supports normal psychological function – adequate folate levels are linked to mood regulation.
• Contributes to normal immune system function – folate supports cell division in immune cells.
• Increased maternal folate status reduces the risk of neural tube defects in babies – a qualified health claim.

Each benefit relies on having a reliable, bio-available folate source. Quatrefolic® is designed for superior absorption, making it an excellent choice for targeted support.

What Makes This Methylfolate Supplement Different?

Many folate supplements use folic acid or calcium-bound 5-MTHF. This product uses Quatrefolic®, the fourth generation of active folate, where methylfolate is bound to glucosamine (non-shellfish derived) rather than calcium. This innovation enhances stability and solubility, promoting better absorption. If you’ve been advised to look for L-methylfolate, Metafolin®, or (6S)-5-MTHF, you’re in the right place—this is the same active molecule, but in a more advanced delivery form.

Folic Acid vs. Methylfolate: Which Is Better?

Folic acid is the synthetic form found in fortified foods and many supplements. It requires conversion by the MTHFR enzyme into active 5-MTHF. However, up to 40-60% of people have genetic variants that impair this conversion, leading to unmetabolised folic acid in the bloodstream. Methylfolate (5-MTHF) bypasses this step, providing the active form directly.

Calcium-bound 5-MTHF (like Metafolin®) is common, but Quatrefolic® uses glucosamine as a carrier, which may offer better stability and absorption. For sensitive individuals or those with MTHFR issues, the glucosamine-bound form can be a gentler, more effective option.

Recommended Dosage

Each vegetarian capsule provides 5000mcg (5mg) of active folate as Quatrefolic®. The bottle contains 60 capsules – a 60-day supply when taking one capsule daily. This dose is well within the tolerable upper intake level for folate (1000mcg from supplementary folic acid, though ULs for 5-MTHF are less established; higher amounts are often used under medical supervision). For general health, many experts suggest 400-800mcg daily, but the 5mg dose is common for those seeking more robust support, such as preconception or homocysteine management. Always follow the label or your practitioner’s advice.

How to Choose a Quality Folate Supplement

• Form: Choose active 5-MTHF (like Quatrefolic®) for direct support.
• Third party testing: This product’s purity, potency, and safety are verified by independent tests, available upon request.
• Allergen-free: Free from common allergens (gluten, soy, dairy), and labelled accordingly.
• Transparency: Clear labelling of ingredient amounts and form, with vegetarian capsules and no unnecessary fillers.
• Brand reputation: Intelligent Labs focuses on quality and scientific backing.

Potential Side Effects and Precautions

Folate is generally well-tolerated, but high doses may cause mild digestive upset, sleep disturbances, or skin reactions in sensitive individuals. Important: high folate intake can mask a vitamin B12 deficiency, delaying diagnosis of pernicious anaemia. If you’re over 50 or follow a vegan diet, ensure adequate B12 intake. Do not exceed recommended dosages without medical guidance. If you have a history of cancer or take medications that interact with folate (like methotrexate), consult your doctor first.

Frequently Asked Questions

Can I take this if I have the MTHFR mutation?
Yes – this product provides the active folate form that bypasses the MTHFR enzyme, making it ideal for those with common variants.

Is this safe during pregnancy?
Many healthcare providers recommend active folate during preconception and pregnancy. Discuss the appropriate dose with your doctor.

How does Quatrefolic® compare to other forms?
Quatrefolic® is a patented form of glucosamine-bound 5-MTHF. It is stable, water-soluble, and designed for superior absorption compared to calcium-bound versions.

Does this contain shellfish-derived glucosamine?
No. The glucosamine is derived from a non-shellfish source, making it suitable for those with shellfish allergies.

This product has not been evaluated by Health Canada. It is not intended to diagnose, treat, , or prevent any disease.