Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

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Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

$60.64

Dresses Size Chart

Dress Size Chart (Inch)

DRESSES SIZE IN INCHES
SIZE	US / CAN	BUST	WAIST	HIPS
XS	0	31"-32"	24"-25"	34"-35"
S	2-4	33"-34"	26"-27"	36"-37"
M	6-8	35"-36"	28"-29"	38"-39"
L	10-12	37"-39"	30"-32"	40"-42"
XL	14	40"-42"	33"-35"	43"-45"

Dress Size Chart (cm)

DRESSES SIZE IN CM
SIZE	US / CAN	BUST	WAIST	HIPS
XS	0	78.7-81.2	60.9-63.5	86.3-88.9
S	2-4	83.8-86.3	66-68.5	91.4-93.9
M	6-8	88.9-91.4	71.1-73.6	96.5-99
L	10-12	93.9-99	76.2-81.2	101.6-106.6
XL	14	101.6-106.6	81.2-88.9	109.2-114.3

Swimwear Size Chart

Dress Size Chart (Inch)

SWIMWEAR SIZE IN INCHES
SIZE	US / CAN	BUST	WAIST	HIPS
XS	0	31"-32"	24"-25"	33"-34"
S	2	33"-34"	26"-27"	35"-37"
M	4	35"-36"	28"-29"	37"-38"
L	6	37"-39"	30"-32"	39"-41"
XL	8	40"-42"	33"-35"	42"-44"

Shoes Size Chart

US	EURO	UK	AUS	JAPAN	CHINA
5	35-36	3	3.5	21.5	35
5.5	36	3.5	4	22	35.5
6	36-37	4	4.5	22.5	36
6.5	37	4.5	5	23	36.5
7	37-38	5	5.5	23.5	37
7.5	38	5.5	6	24	37.5
8	38-39	6	6.5	24.5	38
8.5	39	6.5	7	25	38.5
9	39-40	7	7.5	25.5	39
9.5	40	7.5	8	26	39.5
10	40-41	8	8.5	26.5	40
11	41-42	9	9.5	27.5	41

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Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

$60.64

Description
Additional Information

What Is HER2-Positive Breast Cancer?

HER2 (human epidermal growth factor receptor 2) is a protein that promotes cell growth. In about 20% of breast cancers, the HER2 gene is amplified, leading to overproduction of the protein and aggressive tumour growth. Before targeted therapies, this subtype had a poor prognosis. Herceptin works by binding to the HER2 receptor, blocking growth signals and marking cancer cells for immune destruction. The book provides a clear explanation of this biology, making it accessible to non-scientists.

Book Overview

Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer is a gripping narrative of how a scientific discovery transformed the fight against one of the most aggressive forms of breast cancer. Robert Bazell, a veteran NBC News correspondent, spent years investigating the story behind Herceptin (trastuzumab), from its initial laboratory conception to its eventual FDA approval and widespread clinical use. The book delves into the intricate biology of the HER2 gene, the pressures of the pharmaceutical industry, and the unwavering determination of patients who demanded better treatments. Bazell’s narrative highlights the collaboration between researchers at UCLA and the biotechnology company Genentech, as well as the critical role of clinical trials in establishing safety and efficacy. This book is both a scientific detective story and a human drama, offering readers a front-row seat to a pivotal moment in cancer history.

Who Should Read This Book?

This book is ideal for breast cancer patients and survivors seeking to understand the science behind their treatment. Caregivers and family members will gain insight into the complexities of drug development. Healthcare professionals, including oncologists and researchers, will appreciate the detailed account of clinical trials and regulatory hurdles. Science enthusiasts and readers interested in the history of medicine will find a compelling narrative about innovation. Anyone curious about how a targeted therapy evolves from a laboratory concept to a standard of care will be captivated.

Key Takeaways

Understanding HER2: Learn about the HER2 gene and its role in aggressive breast cancer, and why targeting it is effective.
The Birth of Herceptin: Discover the collaborative research between academia and biotech that produced this monoclonal antibody.
Clinical Trial Milestones: Follow the pivotal trials that demonstrated Herceptin's efficacy and led to FDA approval in 1998.
Patient Advocacy: See how grassroots activism by women with breast cancer pushed for early access and accelerated research.
Scientific Politics: Explore the challenges of patent disputes, corporate mergers, and regulatory decisions that shaped Herceptin's path.
Impact on Oncology: Understand how Herceptin paved the way for personalized medicine and targeted therapies in cancer treatment.

How Did Herceptin Change Breast Cancer Treatment?

Before Herceptin, treatment for HER2-positive breast cancer was limited to chemotherapy, which had modest efficacy. Herceptin specifically blocked the HER2 receptor, halting cancer cell growth. Its approval marked a paradigm shift: the first targeted therapy for a solid tumour based on a genetic marker. Today, Herceptin remains a cornerstone of treatment, often combined with chemotherapy and other agents. The book explains the science behind this revolution and its lasting impact on breast cancer survival rates.

Why Read a Book About Drug Development?

Understanding the path a drug takes from bench to bedside demystifies the process of medical innovation. Her-2 reveals the challenges of funding, regulation, and advocacy that shape which treatments reach patients. For anyone affected by breast cancer, this knowledge empowers informed conversations with healthcare providers. For students and professionals, it exemplifies translational research at its best. The book also raises important questions about access and affordability that remain relevant today.

What Makes This Book on Herceptin Essential Reading?

Unlike many medical histories, Her-2 reads like a thriller. Robert Bazell translates complex immunology into accessible prose without oversimplifying. He details the discoveries of Dr. Dennis Slamon and Dr. Axel Ullrich, the founding of Genentech, and the race to bring Herceptin to market. The book also addresses the ethical dimensions of clinical trials and the high cost of cancer drugs, offering a balanced perspective on breakthrough therapies. It is a rare combination of scientific rigour and human empathy.

This book is not a substitute for professional medical advice. Always consult your healthcare provider for medical guidance.

Important Information

Things You Need to Know

Your payment and personal information are protected using industry-standard SSL encryption, and all payments are securely processed through Shopify-approved payment providers. Prices are displayed in Canadian dollars, and applicable taxes are calculated at checkout.

Orders are generally processed within 1–3 business days. Standard delivery to Canada usually takes 5–15 business days after dispatch. Delivery times are estimates and may be affected by carrier delays, customs processing, weather conditions or other circumstances outside our control. Tracking information will be provided when available.

Return requests must be submitted within 30 days of delivery. Vitamins, supplements and health products must be unused, unopened, sealed and returned in their original packaging. Opened products cannot be returned unless they were delivered damaged, defective or incorrect.

Customers are responsible for return shipping costs for unwanted or change-of-mind returns, and a restocking fee of up to 20% may apply. Damaged, defective or incorrect items must be reported within 48 hours of delivery and may qualify for a replacement or full refund.

Refunds are issued to the original payment method after the returned item has been received and inspected. Refund processing may take up to 7 business days. Before returning any product, please contact our customer support team for return authorization. Returns sent without prior approval may be delayed or rejected.

Approved returns must be sent to:

Return Address Fullfillonus #1202
1128 Lexington Ave, Bldg 4 E
Rochester, New York 14606
United States

Refused or unclaimed shipments may only be refunded after they are returned and inspected. Original shipping charges, return shipping costs, customs fees and carrier charges may be deducted from the refund where applicable.

Vitamin4CA.com is operated by Cloverlight LLC.