{"product_id":"5-mthf-methylfolate-5mg-quatrefolic-active-folate-ca-b01n0qv85s","title":"5-MTHF Methylfolate 5mg, Quatrefolic® for MTHFR Support, 60-day Supply","description":"\u003ch2\u003eWhy Choose Active Folate for MTHFR Support?\u003c\/h2\u003e\u003cp\u003eIf you have an MTHFR gene variant, your body may struggle to convert folic acid into its active form, 5-methyltetrahydrofolate (5-MTHF). This supplement provides 5000mcg of Quatrefolic®, a fourth-generation, glucosamine-bound 5-MTHF that bypasses the conversion step. It’s a direct source of active folate, making it a smart choice for individuals with MTHFR mutations, those planning pregnancy, or anyone seeking a reliable, bio-available form of vitamin B9.\u003c\/p\u003e\u003ch2\u003eWho Should Consider This Supplement?\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWomen planning a pregnancy or during pregnancy:\u003c\/strong\u003e Adequate folate is critical for foetal neural tube development, especially in the first weeks.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIndividuals with MTHFR gene variants:\u003c\/strong\u003e The active form bypasses the MTHFR enzyme, providing direct support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeople with elevated homocysteine levels:\u003c\/strong\u003e Active folate helps support normal homocysteine metabolism, a key factor for cardiovascular health.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThose with low dietary folate intake:\u003c\/strong\u003e If you don’t eat enough leafy greens, beans, or citrus, supplementation can fill the gap.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOlder adults:\u003c\/strong\u003e Folate absorption naturally declines with age, making a potent, absorbable form beneficial.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAlways consult your health care provider before starting a new supplement, especially if you have health conditions or take medications.\u003c\/p\u003e\u003ch2\u003eHealth Benefits of Active Folate\u003c\/h2\u003e\u003cp\u003eFolate contributes to many physiological functions. Health Canada recognizes structure-function claims for active folate, including:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eSupports normal homocysteine metabolism – elevated homocysteine is a risk factor for cardiovascular health.\u003c\/li\u003e\n\u003cli\u003eContributes to the reduction of tiredness and fatigue – folate plays a role in energy metabolism.\u003c\/li\u003e\n\u003cli\u003eSupports normal psychological function – adequate folate levels are linked to mood regulation.\u003c\/li\u003e\n\u003cli\u003eContributes to normal immune system function – folate supports cell division in immune cells.\u003c\/li\u003e\n\u003cli\u003eIncreased maternal folate status reduces the risk of neural tube defects in babies – a qualified health claim.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eEach benefit relies on having a reliable, bio-available folate source. Quatrefolic® is designed for superior absorption, making it an excellent choice for targeted support.\u003c\/p\u003e\u003ch2\u003eWhat Makes This Methylfolate Supplement Different?\u003c\/h2\u003e\u003cp\u003eMany folate supplements use folic acid or calcium-bound 5-MTHF. This product uses Quatrefolic®, the fourth generation of active folate, where methylfolate is bound to glucosamine (non-shellfish derived) rather than calcium. This innovation enhances stability and solubility, promoting better absorption. If you’ve been advised to look for L-methylfolate, Metafolin®, or (6S)-5-MTHF, you’re in the right place—this is the same active molecule, but in a more advanced delivery form.\u003c\/p\u003e\u003ch2\u003eFolic Acid vs. Methylfolate: Which Is Better?\u003c\/h2\u003e\u003cp\u003eFolic acid is the synthetic form found in fortified foods and many supplements. It requires conversion by the MTHFR enzyme into active 5-MTHF. However, up to 40-60% of people have genetic variants that impair this conversion, leading to unmetabolised folic acid in the bloodstream. Methylfolate (5-MTHF) bypasses this step, providing the active form directly.\u003c\/p\u003e\u003cp\u003eCalcium-bound 5-MTHF (like Metafolin®) is common, but Quatrefolic® uses glucosamine as a carrier, which may offer better stability and absorption. For sensitive individuals or those with MTHFR issues, the glucosamine-bound form can be a gentler, more effective option.\u003c\/p\u003e\u003ch2\u003eRecommended Dosage\u003c\/h2\u003e\u003cp\u003eEach vegetarian capsule provides 5000mcg (5mg) of active folate as Quatrefolic®. The bottle contains 60 capsules – a 60-day supply when taking one capsule daily. This dose is well within the tolerable upper intake level for folate (1000mcg from supplementary folic acid, though ULs for 5-MTHF are less established; higher amounts are often used under medical supervision). For general health, many experts suggest 400-800mcg daily, but the 5mg dose is common for those seeking more robust support, such as preconception or homocysteine management. Always follow the label or your practitioner’s advice.\u003c\/p\u003e\u003ch2\u003eHow to Choose a Quality Folate Supplement\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Choose active 5-MTHF (like Quatrefolic®) for direct support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird party testing:\u003c\/strong\u003e This product’s purity, potency, and safety are verified by independent tests, available upon request.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergen-free:\u003c\/strong\u003e Free from common allergens (gluten, soy, dairy), and labelled accordingly.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTransparency:\u003c\/strong\u003e Clear labelling of ingredient amounts and form, with vegetarian capsules and no unnecessary fillers.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrand reputation:\u003c\/strong\u003e Intelligent Labs focuses on quality and scientific backing.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003ePotential Side Effects and Precautions\u003c\/h3\u003e\u003cp\u003eFolate is generally well-tolerated, but high doses may cause mild digestive upset, sleep disturbances, or skin reactions in sensitive individuals. Important: high folate intake can mask a vitamin B12 deficiency, delaying diagnosis of pernicious anaemia. If you’re over 50 or follow a vegan diet, ensure adequate B12 intake. Do not exceed recommended dosages without medical guidance. If you have a history of cancer or take medications that interact with folate (like methotrexate), consult your doctor first.\u003c\/p\u003e\u003ch3\u003eFrequently Asked Questions\u003c\/h3\u003e\u003cp\u003e\u003cstrong\u003eCan I take this if I have the MTHFR mutation?\u003c\/strong\u003e\u003cbr\u003eYes – this product provides the active folate form that bypasses the MTHFR enzyme, making it ideal for those with common variants.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIs this safe during pregnancy?\u003c\/strong\u003e\u003cbr\u003eMany healthcare providers recommend active folate during preconception and pregnancy. Discuss the appropriate dose with your doctor.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHow does Quatrefolic® compare to other forms?\u003c\/strong\u003e\u003cbr\u003eQuatrefolic® is a patented form of glucosamine-bound 5-MTHF. It is stable, water-soluble, and designed for superior absorption compared to calcium-bound versions.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDoes this contain shellfish-derived glucosamine?\u003c\/strong\u003e\u003cbr\u003eNo. The glucosamine is derived from a non-shellfish source, making it suitable for those with shellfish allergies.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eThis product has not been evaluated by Health Canada. It is not intended to diagnose, treat, , or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"Intelligent Labs","offers":[{"title":"Default Title","offer_id":48358266601710,"sku":null,"price":95.63,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0816\/1158\/7822\/files\/51QLs_n8rQL._AC_SL1000.jpg?v=1784588652","url":"https:\/\/vitamin4ca.com\/products\/5-mthf-methylfolate-5mg-quatrefolic-active-folate-ca-b01n0qv85s","provider":"vitamin4ca","version":"1.0","type":"link"}