THORNE Methyl-Guard: Active B12, Folate, B6 for Methylati...

Home THORNE Methyl-Guard - Supports Healthy Methylation* - 180 Capsules

THORNE Methyl-Guard - Supports Healthy Methylation* - 180 Capsules

$130.58

Delivery & Return Ask a Question

Dresses Size Chart

Dress Size Chart (Inch)

DRESSES SIZE IN INCHES
SIZE	US / CAN	BUST	WAIST	HIPS
XS	0	31"-32"	24"-25"	34"-35"
S	2-4	33"-34"	26"-27"	36"-37"
M	6-8	35"-36"	28"-29"	38"-39"
L	10-12	37"-39"	30"-32"	40"-42"
XL	14	40"-42"	33"-35"	43"-45"

Dress Size Chart (cm)

DRESSES SIZE IN CM
SIZE	US / CAN	BUST	WAIST	HIPS
XS	0	78.7-81.2	60.9-63.5	86.3-88.9
S	2-4	83.8-86.3	66-68.5	91.4-93.9
M	6-8	88.9-91.4	71.1-73.6	96.5-99
L	10-12	93.9-99	76.2-81.2	101.6-106.6
XL	14	101.6-106.6	81.2-88.9	109.2-114.3

Swimwear Size Chart

Dress Size Chart (Inch)

SWIMWEAR SIZE IN INCHES
SIZE	US / CAN	BUST	WAIST	HIPS
XS	0	31"-32"	24"-25"	33"-34"
S	2	33"-34"	26"-27"	35"-37"
M	4	35"-36"	28"-29"	37"-38"
L	6	37"-39"	30"-32"	39"-41"
XL	8	40"-42"	33"-35"	42"-44"

Shoes Size Chart

US	EURO	UK	AUS	JAPAN	CHINA
5	35-36	3	3.5	21.5	35
5.5	36	3.5	4	22	35.5
6	36-37	4	4.5	22.5	36
6.5	37	4.5	5	23	36.5
7	37-38	5	5.5	23.5	37
7.5	38	5.5	6	24	37.5
8	38-39	6	6.5	24.5	38
8.5	39	6.5	7	25	38.5
9	39-40	7	7.5	25.5	39
9.5	40	7.5	8	26	39.5
10	40-41	8	8.5	26.5	40
11	41-42	9	9.5	27.5	41

Delivery

Orders are generally processed within 1–3 business days. Standard delivery to addresses in Canada usually takes approximately 5–15 business days after dispatch.

Tracking information will be sent by email when it becomes available. Delivery times are estimates and may be affected by carrier delays, customs, severe weather or circumstances outside our control.

Prices are displayed in Canadian dollars.
Applicable taxes and shipping charges are calculated at checkout.
Orders may be delivered in more than one shipment.
Please verify your shipping address before completing your order.

Returns & Refunds

Return requests must be submitted within 30 days of delivery. Vitamins, supplements and other health-related products must be unused, unopened, sealed and returned in their original packaging.

Opened or used products cannot be returned for health and safety reasons, unless the item arrived damaged, defective or incorrect. Damaged, defective or incorrect items should be reported within 48 hours of delivery.

Customers are responsible for return shipping costs for unwanted or change-of-mind returns. A restocking fee of up to 20% may apply where permitted. Original shipping charges are non-refundable unless the return results from an error on our part.

Refunds are issued to the original payment method after the returned item has been received and inspected. Please allow up to 7 business days for the refund to be processed.

Approved Return Address
Fullfillonus #1202
1128 Lexington Ave, Bldg 4 E
Rochester, New York 14606
United States

Please contact us before sending a return. Returns sent without prior authorization may be delayed, rejected or returned to the sender.

Need Help?

For questions about an order, delivery, return or refund, contact our customer support team and include your order number.

Email: info@cloverlight.net

Vitamin4CA.com is operated by Cloverlight LLC.

THORNE Methyl-Guard - Supports Healthy Methylation* - 180 Capsules

$130.58

Description
Additional Information

Who Can Benefit from Methylation Support?

Are you one of the many Canadians with an MTHFR gene variation? If so, your body may struggle to convert synthetic folic acid into its active form. THORNE Methyl-Guard provides a solution by supplying pre-methylated folate (5-MTHF) and methylcobalamin, bypassing this genetic bottleneck. Vegans and vegetarians, who often have lower B12 intake, can also benefit. Older adults, athletes, and those under physical stress may require additional methylation support. Trusted by over 100 professional sports teams, Thorne is the #1 most recommended clinical brand by consumers and healthcare practitioners (based on a 2026 independent survey), making Methyl-Guard a popular choice for high-quality methylation support.*

Key Benefits for Heart, Brain, and Bone Health

Proper methylation supports cardiovascular health by facilitating homocysteine metabolism, which helps maintain arterial flexibility and heart function.* For the brain, active B vitamins contribute to nerve cell communication and cognitive function. Methylation also influences bone metabolism, supporting bone density and strength.* Each serving delivers 2 mg of 5-MTHF (as calcium folinate), 1 mg of methylcobalamin, 20 mg of vitamin B6 (as pyridoxal 5'-phosphate), and 500 mg of betaine anhydrous — a comprehensive dose to support these vital processes.*

What Makes THORNE Methyl-Guard Special?

Not all B vitamin supplements are created equal. Many contain synthetic folic acid and cyanocobalamin, which require enzymatic conversion and may not be effective for everyone. THORNE Methyl-Guard uses only the active, methylated forms: 5-MTHF (calcium folinate) — the same form found in nature, and methylcobalamin — the coenzyme form of B12. Betaine acts as a direct methyl donor, and vitamin B6 as P-5-P is the active coenzyme form. The formula is free from gluten, dairy, and soy, and is manufactured in a cGMP-compliant facility. Third-party testing ensures purity and potency.

What Is Methyl-Guard and Why Does Methylation Matter?

Methylation is a fundamental biochemical process that occurs in every cell of your body. It plays a critical role in DNA synthesis, gene expression, neurotransmitter production, detoxification, and homocysteine regulation. When methylation pathways are compromised, it can affect cardiovascular, neurological, and skeletal health. THORNE Methyl-Guard is a targeted supplement designed to support optimal methylation by providing the most bioavailable forms of key nutrients: active folate (5-MTHF), active vitamin B12 (methylcobalamin), vitamin B6 (as pyridoxal 5'-phosphate), and betaine (trimethylglycine). These ingredients work synergistically to promote healthy methylation and help maintain homocysteine levels already within a normal range.*

How to Choose a Methylation Support Supplement

When selecting a methylation supplement, consider the following: Ensure folate and B12 are in their active forms (5-MTHF and methylcobalamin). Look for additional methyl donors like betaine or SAMe. Check for vitamin B6 in its active form (P-5-P). Choose a product free from unnecessary additives and allergens. Opt for a reputable brand with transparent quality practises. THORNE meets all these criteria, offering a potent, well-absorbed formula in easy-to-swallow capsules.

Frequently Asked Questions About Methyl-Guard

How should I take Methyl-Guard?

The recommended dose is 2 capsules daily with food. One bottle of 180 capsules provides a 90-day supply. For best absorption, take with a meal containing some fat.

Can Methyl-Guard be taken with other supplements?

Yes, it pairs well with other Thorne products. However, if you are taking medications (especially blood thinners) or have a medical condition, consult your healthcare practitioner before use.

Is Methyl-Guard suitable for vegans?

Yes. The capsules are made from hypromellose (vegetable cellulose) and the formula contains No animal-derived ingredients.

Does Methyl-Guard contain folic acid?

No. It contains calcium folinate (5-MTHF), the active form of folate, making it ideal for those with MTHFR gene variations.

*This product is a natural health product and is not intended to diagnose, treat, , or prevent any disease. Always read the label and follow directions for use.

Important Information

Things You Need to Know

Your payment and personal information are protected using industry-standard SSL encryption, and all payments are securely processed through Shopify-approved payment providers. Prices are displayed in Canadian dollars, and applicable taxes are calculated at checkout.

Orders are generally processed within 1–3 business days. Standard delivery to Canada usually takes 5–15 business days after dispatch. Delivery times are estimates and may be affected by carrier delays, customs processing, weather conditions or other circumstances outside our control. Tracking information will be provided when available.

Return requests must be submitted within 30 days of delivery. Vitamins, supplements and health products must be unused, unopened, sealed and returned in their original packaging. Opened products cannot be returned unless they were delivered damaged, defective or incorrect.

Customers are responsible for return shipping costs for unwanted or change-of-mind returns, and a restocking fee of up to 20% may apply. Damaged, defective or incorrect items must be reported within 48 hours of delivery and may qualify for a replacement or full refund.

Refunds are issued to the original payment method after the returned item has been received and inspected. Refund processing may take up to 7 business days. Before returning any product, please contact our customer support team for return authorization. Returns sent without prior approval may be delayed or rejected.

Approved returns must be sent to:

Return Address Fullfillonus #1202
1128 Lexington Ave, Bldg 4 E
Rochester, New York 14606
United States

Refused or unclaimed shipments may only be refunded after they are returned and inspected. Original shipping charges, return shipping costs, customs fees and carrier charges may be deducted from the refund where applicable.

Vitamin4CA.com is operated by Cloverlight LLC.